About NACC

The National Alzheimer’s Coordinating Center (NACC) was established in 1999 by the National Institute on Aging (NIA) and serves as the centralized data repository, collaboration, and communication hub for the NIA’s Alzheimer’s Disease Research Centers (ADRC) Program.

Over the past 24+ years, NACC has partnered with over 42 current and former ADRCs across the U.S. to build one of the world’s largest and most comprehensive datasets on Alzheimer’s disease and related dementias (AD/ADRD). The NACC Data Platform houses standardized multimodal data on more than 50,000 participants, ranging from cognitively normal individuals to those with mild cognitive impairment or dementia symptoms, with over 17,000 participants actively followed.

Read about NACC's 2024 progress in our 2024 Highlights Letter:

A Year of Progress: NACC’s 2024 Milestones

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NACC is located in the Department of Epidemiology at the University of Washington in Seattle and funded by NIA/NIH cooperative grant U24 AG072122.

The ADRC program

The National Institute on Aging/NIH currently funds 36 ADRCs and 0 Exploratory Centers across the United States. The Centers work to translate research advances into improved diagnosis and care and find ways to treat and possibly prevent Alzheimer's disease and related dementias. Each has its own research focus and recruitment protocol. However, the Centers are all required to involve their entire clinic enrollment in the Uniform Data Set (UDS) study and submit these data to NACC.

The Centers are organized in "cores" (Administrative; Clinical; Data Management & Statistics; Imaging; Neuropathology; Outreach, Recruitment and Engagement; and Biomarker) and "components" (Research Education Component).

For more information on the ADRC Program, please visit the NIA website.

NACC Modernization

NACC relationships with ADRCs, SCAN, NCRAD, ADGC & NIAGADs, NACC and investigators

Help us build a one-stop-shop for all data from the Alzheimer’s Disease Research Centers (ADRC) Program

NACC , NCRAD, and NIAGADS are eager to partner with ADRD researchers and clinicians from across the Alzheimer’s Disease Research Centers (ADRC) Program and beyond to build the “Data Front Door” (DFD), a one-stop-shop for all ADRC data. Our goal is to have this platform integrate and connect all ADRC data streams to NACC IDs and serve as an effective search, visualization, and access interface for this data. NCRAD and NIAGADS data will continue to be housed within the NCRAD and NIAGADS databases but biomarker and genetic metadata for all ADRC participants will be searchable through the DFD.

Our hope is that harmonizing these data streams and connecting them to NACC IDs will enable researchers to investigate and answer new questions in Alzheimer’s disease.

Learn about NACC's work to create a Next Generation Multimodal Data Platform for Discovery and Translation in Alzheimer's Disease:

We welcome you to share your input in two ways:

Sign-up to participate in one of our focus groups with thought leaders from across the ADRC program
Take the survey on Data Front Door Requirements

NACC staff

Leadership Team

Walter A. Kukull, PhD
He/Him
Principal Investigator/Director
Professor, Epidemiology
kukull@uw.edu
Walter A. Kukull, PhD
Principal Investigator/Director
Dr. Kukull's research is focused on the neurodegenerative, vascular and other conditions causing dementia and cognitive impairment. These conditions include Alzheimer's disease, Parkinson's/Lewy body disease, frontotemporal lobar degeneration, and cerebrovascular disease. Since 1999, he has served as Director and PI of the National Alzheimer's Coordinating Center [U24 AG072122], an effort to collect and make available to researchers standardized, detailed clinical data from the approximately 37 NIA-funded Alzheimer Disease Centers across the United States. Dr. Kukull works closely with the leadership of the ADRCs and the National Institute on Aging to ensure that scientifically relevant and valid data are obtained and available from NACC’s database to any researcher anywhere.
In addition to NACC work, he is an investigator with a number of other NIH grants. He is an elected Fellow of: American College of Epidemiology, American Academy of Neurology and American Association for Advancement of Science.

Sarah Biber, PhD
She/Her
Former Executive Director
Sarah Biber, PhD
Former Executive Director
Dr. Sarah Biber was the Executive Director for the National Alzheimer’s Coordinating Center (NACC) from 2021 to 2025. Dr. Biber co-led NACC’s strategic and scientific direction in collaboration with NACC’s PI and Director, Dr. Walter Kukull. Within this role, she represented NACC with national partners, spearheaded national initiatives, led academic and industry partnerships, and oversaw NACC’s tech, operations, research, communications, and grants and finance teams.
Prior to joining NACC, Dr. Biber led the Surgical Innovation Program at Oregon Health and Science University (OHSU) where she shaped and significantly expanded the department of surgery’s innovation capacity and footprint, co-developed surgical innovations, led academic and industry partnerships, and founded the OHSU Invent-a-thon. She previously served as the Assistant Director for NIH’s National Center for Data to Health (CD2H), where she was instrumental in launching the center and led operations to advance informatics innovation, data sharing, software development, and collaboration across the 50+ Clinical Translational Science Awards Program Centers. Prior to CD2H, she was Entrepreneurial Program Director at the Oregon Bioscience Incubator where she helped grow the incubator three-fold and spearheaded statewide partnerships to advance entrepreneurship and startups, served on state-wide committees, and co-founded Accelerate Biotech and Digital Health PDX.