APOE (Apolipoprotein E) genotype is obtained from NCRAD and coded as part of the NACC database for most UDS participants. NACC has developed a data pipeline for distributing APOE genotype data received from NCRAD back to the ADRCs, translating the NCRAD encoding to the NACC encoding in the process. This information will also be available through the Multimodal Query Tool.
In addition, genomic array and sequence data (GWAS, WES/WGS) can be requested from The National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) where it is indexed by NACCID. Researchers who are affiliated with an ADRC can request genomic data on that Center’s own participants directly from the Alzheimer’s Disease Genetics Consortium (ADGC) collection. The genomic data held at NIAGADS, however, are available to all qualified researchers.
The NACC Quick-Access File indicates which ADRC participants have genetic and genomic data available to researchers via NIAGADS, NCRAD, and ADGC