Fluid Biomarker Data
Cerebrospinal Fluid (CSF) Data
For a limited number of UDS participants, cerebrospinal fluid (CSF) biomarker values are available for Aβ, P-tau, and T-tau. Note that the same CSF values can vary by assay method (ELISA, Luminex, etc.) and Center. Centers use different lab assay kits, and ranges for amyloid beta and tau are scaled differently for each brand of kit and have different range and cut off values for positivity. Thus, the values cannot be directly combined in analysis; instead, they will require additional harmonization (not done at NACC currently). To acquire CSF data via the NACC Quick-Access file, submit a data request.
Other Fluid Biomarker Data
Blood based biomarker data has been collected, integrated, and shared in cooperation with the National Centralized Repository for Alzheimer’s Disease (NCRAD). Find out more about NACC's data partnerships.
The NACC Quick-Access File indicates which ADRC participants have fluid biomarker and other biospecimen data available to researchers via NCRAD.
Future Biomarkers
NACC continues to work closely with the ADRC Biomarker Steering Committee to develop requirements for the Fluid Biomarker dataset. Together, we are developing criteria to assist in standardizing fluid biomarker collection, processing, and analysis. The ADRC data will ultimately be integrated into the NACC Data Platform and connected to NACCIDs.
Additional blood biomarker metadata and analysis data for NfL, GFAP, Aβ 42/40, P-tau 181, and other high-impact blood biomarkers prioritized by the ADRC Blood Biomarker Steering Committee.